DMG (Dimethylglycine) and TMG (Trimethylglycine) were among the first nutritional supplements that Kirkman® formulated for special needs individuals. Over the years, we have heard many gratifying stories from our customers about how these supplements have made dramatic differences in their health or their loved ones’ health.
Both are derivatives of the amino acid glycine holding onto methyl groups, in the case of DMG, two methyl groups, while TMG has three methyl groups. When TMG loses one methyl group it can be converted to DMG. Both DMG and TMG are versatile nutrients that offer important health benefits.
DMG, when first discovered, was referred to as Vitamin B-16, however researchers discovered that it did not meet the definition of a vitamin because, unlike vitamins, it can be synthesized in the body and lack of the nutrient has no ill health effects.
DMG supports methylation, methionine metabolism, folate chemistry and is an immune system modulator. DMG is a non-protein amino acid present in plant and animal cells. DMG is considered a “methyl donor” or “methyl bank.” In the body, with the help of a coenzyme of riboflavin, DMG supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body, including cellular perception and response. It is also involved in maintaining healthy homocysteine levels. DMG is present in plant and animal cells.
One of the main benefits of TMG is that it can reduce homocysteine levels in the body to support the heart. Another important role that TMG has is contributing to methylation in the liver to support detoxification processes.
Methyl donors can help in the production of several brain chemicals. Some of the methione from TMG is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body that may support mood, energy, concentration and a feeling of well-being.
Folic acid intake and levels in the body must be adequate for TMG to work biochemically. In some individuals, the use of natural folinic acid may be more beneficial than folic acid because folinic acid already has attached four hydrogen atoms and one methyl group, thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis. These processes are very important in cell perception and response.